Peptidylprolyl Isomerases as In Vivo Carriers for Drugs That Target Various Intracellular Entities
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Peptidylprolyl Isomerases as In Vivo Carriers for Drugs That Target Various Intracellular Entities
Analyses of sequences and structures of the cyclosporine A (CsA)-binding proteins (cyclophilins) and the immunosuppressive macrolide FK506-binding proteins (FKBPs) have revealed that they exhibit peculiar spatial distributions of charges, their overall hydrophobicity indexes vary within a considerable level whereas their points isoelectric (pIs) are contained from 4 to 11. These two families of...
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Peptidylprolyl cis,trans-isomerase (PPIase) activity was detected in the cytosol, mitochondria, and chloroplast of pea plants. Cyclosporin A inhibited the activity largely localized to the mitochondrial matrix while rapamycin inhibited the PPIase activity associated with the mitochondrial membranes. Differential inhibition by the two immunosuppressive drugs, the specific binding of these drugs ...
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ژورنال
عنوان ژورنال: Biomolecules
سال: 2017
ISSN: 2218-273X
DOI: 10.3390/biom7040072